Genome science is integrated into a large variety of life science research, enabling plant scientists to gain insights on the cause of phenotypic variation, species evolution, crop domestication, etc. Understanding genome organization and evolution has been shown as an effective way to design strategies for gene discovery, functional studies, as well as for crop breeding. Indeed, the outcome of a genome project is not only the series of nucleotide sequences, but also the history, biology and possible applications that the sequence data tell us. This course aims to provide students an integrative view of plant genomics through the presentation of various crop plant genomics. The course will also present a selection of molecular mechanisms in plant genomics, as well as applications in basic and applied sciences.